解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Odontogenic sinusitis (OS) presents a therapeutic dilemma. Evidence is lacking whether dental treatment alone is sufficient or whether patients will eventually require endoscopic sinus surgery (ESS). Our aim was to identify predictors of OS patients undergoing ESS. METHODS:Retrospective review performed of ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21736
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Requests from researchers for olfactory mucosal biopsies are increasing as a result of advances in the fields of neuroscience and stem cell biology. Published studies report variable rates of success in obtaining true olfactory tissue, often below 50%. In cases where biopsies are not obtained carefully and c...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21711
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Patient compliance is critical for successful allergen immunotherapy (AIT). Previous studies suggest that AIT compliance is worse outside of controlled clinical trials, with reported subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) noncompliance at 11% to 50% and 3% to 25%, respectively....
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21699
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:The Draf III procedure is an effective endoscopic approach to the treatment of frontal sinus disorders, but has a significant restenosis rate. The objective of the current study is to assess long-term success of the Draf III mucosal grafting technique. METHODS:Patients undergoing Draf III with mucosal graft...
journal_title:International forum of allergy & rhinology
pub_type: 临床试验,杂志文章
doi:10.1002/alr.21708
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Allergic rhinitis (AR) is a complex chronic inflammatory disease of the nasal mucosa, caused by an interaction between genetic and environmental factors. As evidence suggests that some genetic variants may increase susceptibility to both AR and asthma, the objective of this study was to identify asthma susce...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21725
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Diagnostic nasal endoscopy is a routine measure of sinonasal inflammation in patients with chronic rhinosinusitis (CRS). Although multiple staging systems have been proposed and evaluated, evidence of association between concurrent symptoms and endoscopic findings remains discordant. The goal of this study i...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21683
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:The immunologic mechanisms driving inflammation in the upper airways of patients with chronic rhinosinusitis (CRS) are poorly understood. Previous studies have shown that B cells and immunoglobulin E (IgE) levels are elevated in the nasal tissue of patients with atopic chronic rhinosinusitis without nasal po...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21696
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Increased frequency of migraine was reported in adults with allergic rhinitis (AR). Although migraine is less common in children than in adults, it can begin in early childhood and persist into adulthood. We conducted this population-based cohort study to investigate the incidence and subsequent risk of migr...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21654
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Nasal steroids are a critical part of the management of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) after endoscopic sinus surgery (ESS). Increasingly, practitioners are using budesonide respules delivered to the sinonasal cavities, which is an off-label use, in lieu of traditional nas...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,随机对照试验
doi:10.1002/alr.21688
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:The Rhinosinusitis Disability Index (RSDI) consists of multiple subdomains shown to be useful in studying chronic rhinosinusitis (CRS). The objective of this study was to determine if RSDI subdomain scores are associated with selection of treatment modality (endoscopic sinus surgery [ESS] or continued medica...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21656
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:After endoscopic sinus surgery (ESS), endoscopy is used to gauge surgical success and clinical outcomes. Prior studies have not examined this topic prospectively using validated outcome metrics across multiple institutions. METHODS:A multi-institutional, prospective study of patients with chronic rhinosinus...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21651
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:The correct use of inhalation devices is essential for successful therapy. We aimed to evaluate the skills in the use of a spacer device with an metered-dose inhaler (MDI) and factors that influence this skill in asthmatic preschool children's caregivers. METHODS:The caregivers of 12-month-old to 72-month-o...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21648
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Fibroblasts are implicated in tissue remodeling and recruitment of inflammatory cells in chronic rhinosinusitis (CRS). Populations of fibroblasts remain unquantified in CRS subtypes. The objectives of this study were to measure fibroblast populations in subtypes of CRS, and to investigate the association bet...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21636
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:There is a lack of population-based, multi-institutional analyses of factors associated with morbidity and mortality following pituitary tumor excision. METHODS:The American College of Surgeons National Surgical Quality Improvement Project files were used to compile information on patients that had undergon...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21641
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Techniques for inferior turbinate reduction vary from complete turbinectomy to limited cauterization. Surgical methods differ on the degree of tissue reduction and reliance on surgical tissue removal vs tissue ablation. The outcome and morbidity from 3 different turbinate techniques are compared. METHODS:A ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,随机对照试验
doi:10.1002/alr.21574
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Diagnostic strategies employed for cases of cerebrospinal fluid (CSF) rhinorrhea vary widely due to limited evidence-based guidance. METHODS:A systematic review of the literature was performed using PubMed, EMBASE, and Cochrane databases from January 1990 through September 2014, to examine 9 diagnostic and ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21637
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Endoscopic sinus surgery (ESS) enjoys high success rates, but repopulation with pathogenic bacteria is 1 of the hallmarks of poorer outcomes. There are many hypothesized sources of repopulating bacteria; however, this process remains largely unexplored. This study examined changes in the sinus microbiome aft...
journal_title:International forum of allergy & rhinology
pub_type: 临床试验,杂志文章
doi:10.1002/alr.21630
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:There are major differences in the clinical pattern of allergic rhinitis (AR) patients among countries, reflecting local aerobiological conditions. We analyzed the correlation between airborne pollen concentrations of the Western Thrace/northeast (NE) Greece region with symptoms scores in AR patients. The ab...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21623
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Olfaction is one of the important senses for humans. Systemic glucocorticoids are the most commonly used medications for olfactory loss because of their strong anti-inflammatory effects. However, their effect on olfactory function is still controversial and the precise mechanism is not clear. To gain a globa...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21586
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a common condition encountered in primary care medicine and is estimated to affect 12.5% of the United States population. This study aims to compare methods of assessing health utility in CRS. METHODS:A cross-sectional sample of CRS patients (n = 137) were interviewed using d...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21556
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Sufficient clinical data are not available on the effect of hypothyroidism on olfactory function in adults. In this study, we aimed to evaluate the olfactory function of adult patients diagnosed with primary hypothyroidism. METHODS:Forty-five patients aged between 18 and 60 years who were diagnosed with cli...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21565
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:The role of bacteria in the pathogenesis of chronic rhinosinusitis (CRS) remains uncertain. Recent evidence suggests that bacteria are able to establish microcolonies within the underlying mucosa. However, to date there has been no systematic comparison of bacterial community composition and diversity in the...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21600
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether anterior rhinoscopy (AR), nasal endoscopy (NE) and paranasal sinus computed tomography (PNS CT) can predict other sinonasal obstructive pathologies in the setting of nasal septal deviation (NSD), and to evaluate the impact of preoperative PNS CT on the decision ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21545
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:The relationship between olfactory function, rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin' Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21550
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Bronchial asthma is one of the most common chronic diseases in childhood, with a current prevalence of 6% to 9%, but a prevalence that is increasing at an alarming rate. Asthma is a complex genetic disorder with strong environmental influence. It imposes a growing burden on our society in terms of morbidity,...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21557
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:As part of this primer, this article is intended to introduce new and emerging therapies for treating asthma. METHODS:A PubMed search was performed for the years 2013 through 2015 for asthma review, asthma treatment, asthma therapy, and asthma new. Subset searches were additionally performed as suggested by...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21611
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:The role of human papillomavirus (HPV) in sinonasal inverted papillomas (IPs) is controversial. Determining the prevalence of HPV infection and its impact on the molecular biology of these tumors is critical to characterizing its role in the pathogenesis of IPs. METHODS:A total of 112 paraffin-embedded IPs ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21524
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:The mechanism of airway remodeling in chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unknown. We wished to determine whether profibrotic transforming growth factor beta 1 (TGF-β1) and activin A and their downstream signaling proteins are increased in CRSwNP and if they are regulated in epitheli...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21516
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:In this prospective, multicenter, randomized, controlled, double-blind study, we investigated the impact of a mobile patient engagement application on health outcomes and quality of life in allergic rhinitis (AR) and asthma patients. METHODS:In total, 327 patients with diagnoses of persistent AR or mild-to-...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/alr.21468
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:There has been no study investigating nonsteroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (NERD) exclusively in childhood. Therefore, in the current study, the authors aimed to evaluate the diagnostic features, clinical characteristics, and follow-up of adolescents diagnosed with NE...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21494
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Current clinical classifications of chronic rhinosinusitis (CRS) have been largely defined based upon preconceived notions of factors thought to be important, such as polyp or eosinophil status. Unfortunately, these classification systems have little correlation with symptom severity or treatment outcomes. U...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21496
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Treatment of recalcitrant chronic rhinosinusitis (CRS) is a challenge with increasing antibiotic resistance, leading to re-emergence of topical therapies. The aim of this study was to assess safety and efficacy of topical colloidal silver solution for the treatment of Staphylococcus aureus biofilms in a shee...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21459
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Debate still persists on the relation between olfactory bulb volume (OBV) and olfactory function. Many studies suggest that olfactory deprivation decreases the OBV. The aim of this study was to compare the olfactory threshold and OBV of patients with nasal polyps to healthy individuals and to evaluate the im...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21478
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Endoscopic-endonasal skull base surgery (ESBS) provides an important approach to select pathologies. There remains a paucity of data, however, regarding morbidity in patients undergoing ESBS with comorbid acute rhinosinusitis (ARS), a fungal ball (FB), or chronic rhinosinusitis (CRS). METHODS:A retrospectiv...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21476
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:We have previously demonstrated that persistent symptoms following functional endoscopic sinus surgery for chronic rhinosinusitis (CRS) is associated with Gram-negative bacterial carriage. Mechanisms for this remain unknown. We wished to determine whether Gram-negative carriage in patients with CRS with nasa...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21481
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Many asthmatic patients have coexisting allergic rhinitis (AR). This study aims to investigate the compliance of physicians with respiratory medicine specialty (PRMs) to Global Initiative for Asthma (GINA) and Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines during the management of their asthma-...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21449
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Nasal polyposis is characterized by persistent inflammation but the pathogenesis is complex and still debatable. Autophagy has been associated with many human health problems including chronic inflammatory airway diseases. Whether autophagy plays a role in nasal polyps and could be a therapeutic target is co...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21456
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Chronic sinusitis is universal in cystic fibrosis (CF) and our current treatments are ineffective in reversing sinus disease. The objective of this work was to determine if increasing CF transmembrane conductance regulator (CFTR) activity by ivacaftor could treat CF sinus disease and assess its effect on pri...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21440
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Antibiotics are commonly used in the management of both acute rhinosinusitis and acute exacerbations of chronic rhinosinusitis. With their common use, they have become the leading medication for litigation. It is crucial for the provider to be familiar with potential complications and the medico-legal ramifi...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21433
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Variants of squamous cell carcinoma (SCC) make up 15% of all cases of SCC of the upper aerodigestive tract. There are 5 main histologic variants of SCC in the head and neck region: verrucous (VSCC), papillary (PSCC), spindle cell (sarcomatoid) (SCSC), basaloid (BSCC), and adenosquamous (ASC). Conventional si...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21418
更新日期:2015-01-01 00:00:00